个人简介:

张红星,女,医学博士,教授、主任医师,硕士生导师,马来西亚理科大学联合培养博士生导师,从事精神疾病生物学机制与临床相关研究。曾获得“全国卫生系统先进个人,教育部新世纪优秀人才、中原英才系列-中原科技领军人才,河南省科技创新杰出青年、河南省学术技术带头人、河南省优秀中年卫生科技新人才,河南省师德先进个人,河南省教育厅学术技术带头人、河南省医学学术技术带头人”等称号。中国神经科学学会精神病学基础与临床分会委员,河南省医学会精神科专业委员会常委,河南省心理卫生协会常务理,河南省医学科学普及精神卫生分会常务委员

主持国家自然科学基金面上项目3项,国家重点研发项目课题1项,教育部新世纪优秀人才支持计划1项,省级项目6项,获河南省科技进步奖三等奖1项,以第一作者或通讯作者发表论文64篇,其中SCI期刊源论文27篇;参编教材7部。

教育与工作经历:

1997.07-2001.09 河南省卫生学校 药理教研室教师,从事临床药物学教学工作;

2007.06-2009.07 437必赢会员中心第二附属医院(河南省精神病医院)临床心理

科医生,副教授

2009.07-2013.11 437必赢会员中心第二附属医院(河南省精神病医院)科教科,

副主任医师/副教授,科教科科长;

2013.11-至今 437必赢会员中心心理学院,教授/主任医师,心理学院  

联系方式:

Zhx166666@163.com

研究兴趣及方向:

精神症状认知生理心理机制

主要学术职务与荣誉称号:

1.教育部新世纪优秀人才 2012

2.河南省教育厅学术技术带头人 2012

3.河南省卫生厅:河南省卫生科技管理先进个人,20122

4.全国卫生系统先进工作者    中华人民共和国人力资源和社会保障部、卫生部和国家中医药管理局2012.9

5.河南省优秀中青年卫生科技创新人才  2012.9.27

6.河南省师德先进个人 2016

7.河南省学术技术带头人 2016

8.河南省科技创新人才杰出青年 2016

9.河南省文明教师2019

10.中原千人计划:河南省科技创新领军人才2019.12

11.河南省高层次人才2020

12.河南省卫生科技创新型人才工程中青年科技创新人才 2015

研究项目:

12011,国家自然科学基金,基因功能SNPsDNA甲基化共同影响精神分裂症易感性机制研究,81071091

22015,国家自然科学基金,电休克刺激对SD大鼠脑中枢神经系统可塑性的影响(81571315),2016.01-2017.12.

32017,国家重点研发计划资助(2016YFC1306700)抑郁障碍临床诊断、干预与转归的客观标记物研究(2016YFC1306704),2016 07 月 —— 2020 12 月,77万元 课题四:MDD发病和复发风险评估模型及诊断工具包开发应用

42017年申报,河南省高校科技创新团队,精神疾病认知生理心理机制研究团队(18IRTSTHN025):2018.01-2019.12

52017,国家自然科学基金-河南省联合基金重点培育项目。多维度关联分析脑白质功能相关基因筛选精神分裂症生物学标记(U1704190)L02,,2018.01.01-2020.12.31

6.中共河南省委组织部,河南省人力资源和社会保障厅 中原千人计划-中原科技创新领军人才。基于认知图式的冷执行功能训练对抑郁症患者的康复作用及脑影像学机制2042005100202020.01.01-2022.12.31 Zhongyuan One Thouthand Talents Program (204200510020)

72011,新世纪优秀人才支持计划,基于全基因组DNA甲基化筛选基础上的精神分裂症患者目的基因甲基化状态检测,NCET-10-01372010.01-2014.1250.

82018 河南省科技创新人才(杰出青年)计划174100510024,基于汇聚功能基因组学信息建立精神分裂症遗传影像学联合诊断标记. 2017.01-2018.12, 30.

92010,河南省科技厅发展计划,基因功能SNPsDNA甲基化共同影响精神分裂症易感性机制研究,102102310153. 2010.01-2012.12

102008,河南省科技厅发展计划,Neuregulin-1基因多态性及其功能表达与精神分裂症,082102300812009.01-2011.12

112010,河南省高校青年骨干教师,候选基因甲基化状态与精神分裂症的关联研究,2010GGJS-1162010.01-2012.12.

122012,河南省医学学术技术带头人出国研修项目:精神分裂症患者主动式社区康复模式探索,河南省卫生厅,10.29.2012.01-2013.01

132013,河南省卫生厅  河南卫生科技创新型人才工程优秀人员项目,精神疾病全基因组关联分析与药物基因组学研究(cxyx20130418. 2013.01-2015.12

14.主动式社区康复模式下慢性精神疾病患者心理干预模式探索,2014-GH-643 完成时间:2015.04

152015,河南省科技厅,电休克剌激对精神分裂症模型大鼠脑神经元网络振荡的影响,(152300410122),2015.01-2017.12. 5万元

学术论文与专著:

1Hong-Xing Zhang, Zhao JP, Lv LX, Li WQ, Xu L, Ouyang X, Yuan ZQ, Huang JS. Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia. Neuroscience letters 2008 24(5):1-5.IF=2.2ISSN:0304-3940

2Li W, Wang X, Zhao J, Lin J, Song X, Yang Y, Jiang C, Xiao B, Yang G, Zhang H*(通讯作者), Lv L*. Association Study of myelin transcription factor 1-like polymorphisms with schizophrenia in Han Chinese population. Genes Brain Behav. 2012 Feb;11(1):87-93.. IF=4.061ISSN:1601-1848

3Yanshen Jiang, Hongxing Zhang*, Zifan Wang, Ling Zhao, Luxian Lv*. Effects of modified electroconvulsive therapy on the cognitive function and blood parameters in female patients with schizophrenia Int ernational Journal of Clinical and Experimental Medicine Int J Clin Med.2015;8(1):1349-1355 ISSN 1940-5901. IF=1.277

4Zhao Ling, Jiang Yansheng, Zhang Hongxing*. Effects of modified electroconvulsive therapy on the electroencephalogram of schizophrenia patients. SpringerPlus2016;5(1): 1063. ISSN: 2193-1801IF=0.982

5Liang Gong, Yingying Yin, Cancan He, Qing Ye, Feng Bai,Yonggui Yuan, Haisan Zhang, Luxian Lv, Hongxing Zhang*, Chunming Xie*, Zhijun Zhang. Disrupted reward circuits is associated with cognitive deficits and depression severity in major depressive disorder. Journal of Psychiatric Research. 2017 Jan;84:9-17. ISSN:0022-3956IF=4.465

6Yi Yu, Yun Zhao, Yajing Si, Qiongqiong Ren, Wu Ren, Changqin Jing and Hongxing Zhang*. Estimation of the cool executive function using frontal electroencephalogram signals in firstepisode schizophrenia patients. BioMed Eng OnLine 2016 Nov 25;15(1):131-145  ISSN: 1475-925X (IF=1.682)

7Liang Gong, Cancan He, Haisan Zhang, Hongxing Zhang*, Zhijun Zhang, Chunming Xie*. Disrupted reward and cognitive control networks contribute to anhedonia in depression, Psychiatry research. J Psychiatr Res. 2018 Aug;103:61-68. doi: 10.1016/j.jpsychires.2018.05.010. Epub 2018 May 12.

8He C, Gong L, Yin Y, Yuan Y, Zhang H, Lv L, Zhang X, Soares JC, Zhang H, Xie C, Zhang Z. Amygdala connectivity mediates the association between anxiety and depression in patients with major depressive disorder. Brain Imaging Behav. 2019;13(4):1146-1159. doi: 10.1007/s11682-018-9923-z.IF=3.391

9Li, K., Zhang, H., Wang, B., Yang, Y., Zhang, M., Li, W., Li, X., Lv, L., Zhao, J., & Zhang, H. (2020). Hippocampal functional network: The mediating role between obsession and anxiety in adult patients with obsessive-compulsive disorder.  The world journal of biological psychiatry., 2020 Nov;21(9):685-695. doi: 10.1080/15622975.2020.1733082. Epub 2020 Mar 16.  IF2020=4.132

10Kun Li# , Haisan Zhang# , Yongfeng Yang, Jianli Zhu , Bi Wang , Yanli Shi , Xianrui Li,,Meng Zhang, Luxian Lv , Hongxing Zhang*, Abnormal functional network of the thalamic subregions in adult patients with obsessive-compulsive disorder, Behavioural Brain Research, 2019 May 26;371:111982. IF=3.327  ISSN : 0166-4328

11Xianrui Li, Meng Zhang, Kun Li, Feng Zou, Yufeng Wang, Xin Wu and Hongxing Zhang* The Altered Somatic Brain Network in State Anxiety. Frontier in Psychiatry.2019,07 IF=3.161  ISSN: 1664-0640

12Haisan Zhang, Bi Wang, Kun Li, Xiaoyue Wang, Xianrui Li, Jianli Zhu, Qingjiang Zhao, Yongfeng Yang, Luxian Lv, Meng Zhang  and Hongxing Zhang*.Altered Functional Connectivity Between the Cerebellum and the Cortico-Striato-Thalamo-Cortical Circuit in Obsessive-Compulsive Disorder. Frontier in Psychiatry. 20190710:522 P1-8. IF=3.161  ISSN: 1664-0640

13Li K, Zhang M, Zhang H, Li X, Zou F, Wang Y, Wu X, Zhang H*.The spontaneous activity and functional network of the occipital cortex is correlated with state anxiety in healthy adults. Neurosci Lett. Neurosci Lett. 2020;715:134596. doi:10.1016/j.neulet.2019.134596  IF2020=3.046

14Zhijun Zhang #, Hongxing Zhang # , Chun-Ming Xie # , Meng Zhang # , Yachen Shi , Ruize Song , Xiang Lu , Haisan Zhang , Kun Li , Bi Wang , Yongfeng Yang , Xianrui Li , Jianli Zhu , Yang Zhao , Ti-Fei Yuan , Georg Northoff. Task-related functional magnetic resonance imaging-based neuronavigation for the treatment of depression by individualized repetitive transcranial magnetic stimulation of the visual cortex. Sci China Life Sci. 2021 Jan;64(1):96-106.  IF=6.03

15Xinyi Liu , Cancan He , Dandan Fan , Yao Zhu , Feifei Zang , Qing Wang , Haisan Zhang , Zhijun Zhang , Hongxing Zhang *, Chunming Xie * Disrupted rich-club network organization and individualized identification of patients with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Aug 18;110074. IF=4.263

16Xiaoxiao Shan Haisan Zhang  Zhao Dong indong Chen Feng Liu5 Jingping Zhao Hongxing Zhang Wenbin Guo. Increased subcortical region volume induced by electroconvulsive therapy in patients with schizophrenia. European Archives of Psychiatry and Clinical Neuroscience. 2021 Oct;271(7):1285-1295. doi: 10.1007/s00406-021-01303-6. Epub 2021 Jul 17. IF2021=5.760

17Tong W, Dong Z, Guo W, Zhang M, Zhang Y, Du Y, Zhao J, Lv L, Liu Y, Wang X, Kou Y, Zhang H, Zhang H.  Progressive Changes in Brain Regional Homogeneity Induced by Electroconvulsive Therapy Among Patients With Schizophrenia. J ECT. 2022 Jun 1;38(2):117-123. doi: 10.1097/YCT.0000000000000815. PMID: 35613010.  IF= 3.692 ISSN1095-0680

18Liu Y, Zhang J, Zhang M, Li X, Li K, Wang B, Yang Y, Song R, Si Y, Ni T, Wang X, Geng Y, Chang Q, Zhang H, Zhang Z, Zhang H. Abnormal brain gray matter volume in patients with major depressive disorder: Associated with childhood trauma? J Affect Disord. 2022 Apr 20;308:562-568.  (IF2022=6.533) ISSN0165-0327

19Si Y, Liu C, Kou Y, Dong Z, Zhang J, Wang J, Lu C, Luo Y, Ni T, Du Y, Zhang H.Antipsychotics-induced improvement of cool executive function in individuals living with schizophrenia. Front Psychiatry. 2023 Apr 27;14:1154011.

20Si Y, Li P, Wang X, Yao G, Liu C, Liu Y, Zhang J, Zhang H, Luo Y. Cueing effect of attention among nurses with different anxiety levels: an EEG study. Med Biol Eng Comput. 2023 Mar 29.