王磊，男，1979年出生，博士，硕士研究生导师。
联系方式：
H/P: 13462389905
e-mail: lwang0522@163.com
教育经历:
2009.01-2012.12，新加坡南洋理工大学，细胞病毒学，博士
2003.09-2006.07，厦门大学，生物化学与分子生物学，硕士
1999.09-2006.07，聊城大学，生物教育，本科
工作经历:
2013/08-至今， 437必赢会员中心生命科学技术学院，讲师
专业研究方向
肿瘤生物学
主要科研工作简介
1.具体研究领域
黑色素瘤增殖和转移的分子机制
2.课题资助
1）NSFC-河南联合基金培育项目：E3泛素连接酶环指蛋白11(RNF11)通过降解Syk促进黑色素瘤转移的分子机制研究（2017.01-2019.12 主持）
2）河南省高等学校重点科研项目计划：环指蛋白11通过转化生长因子-β促进黑色素瘤转移的分子机制（2015.01-2016.12 主持）
3）437必赢会员中心科研培育基金：环指蛋白11在黑色素瘤转移过程中的分子机制研 （2013.11-2016.12主持）
4）437必赢会员中心博士启动基金：环指蛋白11促进黑色素瘤转移的分子机制研究 （2014.09起）
3.近期代表性论文（已发表SCI论文30篇）
1)Bin-Feng Cheng, Yao-Xin Gao, Jun-Jiang Lian,Dan-Dan Guo, Lei Wang,* Mian Wang, Hai-Jie Yang*and Zhi-Wei Feng. Hydroxysafflor yellow A inhibits IL-1β-inducedrelease of IL-6, IL-8, and MMP-1 via suppression ofERK, NF-κB and AP-1 signaling in SW982 humansynovial cells. Food & Function, DOI: 10.1039/c6fo01045h(* corresponding author).
2)Lei Wang,Qiong-Qiong Ding,Shan-Shan Gao,Hai-Jie Yang,Mian Wang,Yu Shi,Bin-Feng Cheng,Jia-Jia Bi,Zhi-Wei Feng.PRDM5 promotes the proliferation and invasion of murine melanoma cells through up-regulating JNK expression. Cancer Medicine,2016; 5(9):2558–2566.
3)Yan Wang, Chen-yan Zhou, Hong Ming, Jing Kang, Hong-li Chen,Chang-qin Jing, Hui-gen Feng, Ya-ke Chang, Zhen-hao Guo,Lei Wang*. Pseudofulvibacter marinus sp. nov., isolatedfrom seawater. International Journal of Systematic and Evolutionary Microbiology, 2016, (66), 1301–1305(*corresponding author).
4)Lei Wang, Hai-Jie Yang, Shan-Shan Gao, Mian Wang, Yu Shi, Bin-Feng Cheng and Zhi-Wei Feng. Identification of a novel role of RING finger protein 11 promoting the metastasis of murine melanoma cells. Am J Transl Res, 2015, 7(9): 1629–1635.
5)Lei Wang,Bin-Feng Cheng, Hai-Jie Yang, Mian Wang, Zhi-Wei Feng.NF-κB protects human neuroblastoma cells from nitric oxide-induced apoptosis through upregulating biglycan. Am J Transl Res,2015, 7(9):1541-1552.
6)Hai-Jie Yang,Lei Wang,Mian Wang,Shuang-Ping Ma, Bin-Feng Cheng,Zhi-Chao Li, Zhi-Wei Feng.Serine/Threonine-protein kinase PFTK1 modulates oligodendrocyte differentiation via PI3K/AKT pathway. J Mol Neurosci, 2015, 55:977-984.
7)Hai-Jie Yang,Lei Wang,Shu-LiChen, Mian Wang,Zhi-Wei Feng.Effect of a double-structured microporous polymer support on the catalytic activity, stability and aggregation behavior of immobilized enzymes. Polymer Int, 2015, 64(7):915-923.
8)Hai-Jie Yang, Pei Feng, Lei Wang, Zhi-Chao Li, Shuang-Ping Ma, Mian Wang, Zhi-Wei Feng. Caveolin-1 mediates genetransfer and cytotoxicity of polyethyleneimine in mammalian cell lines.Mol Cell Biochem, 2015, 402: 203-211.
9)Hai-Jie Yang, Mian Wang , Lei Wang, Bin-Feng Cheng, Xiao-Yu Lin, Zhi-Wei Feng, NF-κB regulates caspase-4expression and sensitizes neuroblastoma cells to Fas-induced apoptosis.PLoSOne, 2015, 10(2): e0117953-e0117953.
10)Lei Wang, Yu Shi, Peijun Ju, Rui Liu, Siok Ping Yeo, Yinyan Xia, Zhiwei Feng. Silencing of diphthamide synthesis 3 (Dph3) reduces metastasis of murine melanoma. PLoS ONE, 2012, 7(11):e49988. doi: 10.1371/journal.pone.0049988.
11)Yu Shi, Yin-Yan Xia, Lei Wang,Rui Liu, King-Shung Khoo, Zhi-Wei Feng. Neural Cell Adhesion Molecule modulates Mesenchymal Stromal Cell migration via activation of MAPK/ERK signaling. Experimental cell research,2012,318(17), 2257-67.
12)Bin Zhi, Lei Wang, Guangyi Wang, Xiaobo Zhang. Contribution of the caspase gene sequence diversification to the specifically antiviral defense in invertebrate. PLoS ONE, 2011, 6, e24955.
13)Rui Liu, Yu Shi, Hai Jie Yang, Lei Wang, Si Zhang, Yin Yan Xia, Jing Lin Jack Wong, and Zhi-Wei Feng. Neural Cell Adhesion Molecule Potentiates the Growth of Murine Melanoma via β-Catenin Signaling by Association with Fibroblast Growth Factor Receptor and Glycogen Synthase Kinase-3β. Journal of Biological Chemistry, 2011, 286, 26217-26317.
14)Hai-Jie Yang, Yin-Yan Xia, Lei Wang, Goh-Kim Jee, Yu Shao, Zhi-Wei Feng. A novel role forneural cell adhesion molecule in modulating insulin signaling and adipocyte differentiation of mouse mesenchymal stem cells. Journal of Cell Science, 2011, 124, 2552-2560.
15)Lei Wang, Hai-Jie Yang, Yin-Yan Xia, Zhi-Wei Feng. Insulin-like growth factor 1 protects human neuroblastoma cells SH-EP1 against MPP+-induced apoptosis by AKT/GSK-3β/JNK signaling. Apoptosis, 2010, 15 (12), 1470-1479.
16)Hai-Jie Yang, Lei Wang, Yin-Yan Xia, Piek-Ngoh Chang, Zhi-Wei Feng. NF-kappaB mediates MPP+-induced apoptotic cell death in neuroblastoma cells SH-EP1 through JNK and c-Jun/AP-1. Neurochemistry International, 2010, 56:128-134.
17)Lei Wang, Bin Zhia, Wenlin Wua, Xiaobo Zhang. Requirement for shrimp caspase in apoptosis against virus infection. Developmental and Comparative Immunology, 2008, 32, 706–715.
18)Wenlin Wu, Lei Wang, Xiaobo Zhang. Identification of white spot syndrome virus (WSSV) envelope proteins involved in shrimp infection. Virology, 2005, 332, 578–583 (Co-first authorship)
