王洁(1982.6-),理学博士,副教授,硕士生导师,河南省优秀青年基金获得者,目前研究方向为分子免疫学,主要从事感染免疫和炎症性肠病相关方面的研究。
【受教育经历】
2000.09-2004.06 山东大学 生物科学专业 学士
2004.09-2011.10中国科学院上海生命科学研究院生化细胞所 细胞生物学专业 博士
【研究工作经历】
2012.04-2013,06,中国科学院上海生命科学研究院营养所 博士后
2013.7-2018.4 437必赢会员中心医学检验学院 讲师
2018.5-至今 437必赢会员中心医学检验学院 副教授
2018.04-2022.07 美国克利夫兰医学中心 博士后
【承担及完成国家级/省级课题】
1. Sirt2在RNA病毒感染及感染后器官损伤中的功能和机制研究(222300420064),河南省自然科学基金-优秀青年科学基金,2022.01-2024.12,25万元;
2. Sirt4调控cGAS介导的抗病毒固有免疫应答反应的功能和机制研究(32170871),国家自然科学基金面上项目,2022.01-2025.12,58万元;
3. RNF144A调控MITA/STING介导的固有免疫应答反应的功能和机制研究(31970847),国家自然科学基金面上项目,2020.01-2023.12,59万元;
4. RNF90调控MITA/STING介导的胞内抗病毒应答反应的研究(31600697),国家自然科学基金青年项目,2017.01-2019.12,20万元;
5. Ku70负性调控HTLV-1病毒感染的功能和机制研究(U1504811),国家自然科学基金联合基金项目,2016.01-2018.12,25万元。
【代表性论著】(#为第一作者,*为通讯作者)
(1)Jie Wang#,Idan Goren,Bo Yang,Sinan Lin,Jiannan Li,Michael Elias,Claudio Fiocchi,Florian Rieder*. The Sphingosine 1 phosphate/Sphingosine 1 phosphate receptor axis-a unique therapeutic target in inflammatory bowel disease. Aliment Pharmacol Ther. 2022 ; 55(3):277-291
(2)Jie Wang#,Florian Rieder*. A single-cell atlas of fibroblasts one size does not fit all. Nat Rev Gastroenterol Hepatol. 2021 ; 18(9):595-596.
(3)Jie Wang#,Sinan Lin#,Jonathan Mark Brown,David van Wagoner,Claudio Fiocchi,Florian Rieder*. Novel mechanisms and clinical trial endpoints in intestinal fibrosis. Immunol Rev. 2021 ; 302(1):211-227
(4)Bo Yang#,Ge Zhang#,Xiao Qin#,Yulu Huang,Xiaowen Ren,Jingliang Sun,Shujun Ma,Yanzi Liu,Di Song,Yue Liu,Yuhan Cui,Hui Wang*,Jie Wang*. Negative regulation of RNF90 on RNA virus-triggered antiviral immune responses targeting MAVS. Front Immunol. 2021 ; 12: 730483.
(5) Yang, B#; Liu, Y#; Cui, Y#; Song, D; Zhang, G; Ma, S; Liu, Y; Chen, M; Chen, F; Wang, H*;Wang, J.*; RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation, PLoS Pathogens, 2020 ;16(3):e1008387.
(6)Bo Yang#,Ge Zhang#,Michael Elias,Yijun Zhu,Jie Wang*. The role of cytokine and immune responses in intestinal fibrosis. J Dig Dis. 2020 ; 21(6):308-314.
(7) Yang, Bo#; Song, Di#; Liu, Yue; Cui, Yuhan; Lu, Guangjian; Di, Wenyu; Xing, Hongxia; Ma, Lingling; Guo, Zhixiang; Guan, Yuhe; Wang, Hui*;Wang, Jie*; IFI16 regulates HTLV-1 replication through promoting HTLV-1 RTI-induced innate immune responses. FEBS Letters, 2018,;592(10): 1693-1704.
(8)Wang, Jie#; Kang, Lixia; Song, Di; Liu, Lu; Yang, Shuai; Ma, Lingling; Guo, Zhixiang; Ding, Huaxia; Wang, Hui*; Yang, Bo*; Ku70 Senses HTLV-1 DNA and Modulates HTLV-1 Replication. , The Journal of Immunology, 2017;199(7): 2475-2482.
(9)Wang, Jie#; Song, Di#; Liu, Yanzi; Lu, Guangjian; Yang, Shuai; Liu, Lu; Gao, Zhitao; Ma, Lingling; Guo, Zhixiang; Zhang, Chenguang; Wang, Hui*; Yang, Bo*; HLA-DMB restricts human T-cell leukemia virus type-1 (HTLV-1) protein expression via regulation of ATG7 acetylation. , Scientific Reports, 2017;7(1): 14416-14416.
(10)Jie Wang#,Shuai Yang,Lu Liu,Hui Wang*,Bo Yang*. HTLV-1 Tax impairs K63-linked ubiquitination of STING to evade host innate immunity, Virus Res. 2017 ; 232:13-21.