基本信息:
张黎琛(1983.03-),博士,讲师,硕士生导师。研究方向为免疫模式动物及免疫炎症相关研究,主要从事T细胞抗血吸虫病的作用机制以及免疫细胞在动脉粥样硬化形成中的机制研究。主持国家自然科学基金面上项目1项、主持完成国家自然科学基金青年项目1项及河南省科技攻关计划项目1项。作为免疫表型组学中心的骨干成员,主要负责动物遗传模型的设计构建以及细胞系基因编辑技术的研发。
教育经历:
(1)2008-09至2011-11, Aix-Marseille University(法国艾克斯-马赛大学),微生物学,博士,微生物学,导师:Cheng-Cai Zhang
(2)2006-09至2008-08,华中农业大学,微生物学,硕博连读,农业微生物学国家重点实验室,蓝细菌分子生物学,导师:陈雯莉
(3)2002-09至2006-06,华中农业大学,生物科学,理学学士,国家生物学理科基地班
科研与学术工作经历:
(1)2013-11至现在,437必赢会员中心,医学检验学院,讲师
(2)2013-03至2013-09,法国马赛免疫中心(CIML), Bernard MALISSEN法国科学院院士实验室,博士后, T细胞活化相关功能基因的研究
(3)2012-05至2013-02,法国地中海微生物研究所(IMM-LCB), Long-Fei Wu实验室,博士后,在新型趋磁细菌中建立其遗传转化体系
主持或参加科研项目情况:
(1)国家自然科学基金委员会,面上项目,磷酸酶Ptprc突变激活CD36/Vav/JNK信号轴促进泡沫细胞分化的机制, 2022-01至2025-12, 58.0000万元,主持
(2)国家自然科学基金委员会,青年项目, 81601360, T细胞对非适应性宿主抗血吸虫病的作用, 2017-01至2019-12, 17.5000万元,已结题,主持
(3)国家自然科学基金委员会,面上项目, 32070898, LAT介导的负反馈障碍导致T细胞增殖失控的机制, 2021-01至2024-12, 58.0000万元,在研,参加
(4)国家自然科学基金委员会,面上项目, 81471595, CD28缺失加剧NOD小鼠T细胞活化的机制研究, 2015-01至2018-12, 70.0000万元,已结题,参加
(5)国家自然科学基金委员会,面上项目, 81471559, Bcl3对HTLV-1病毒感染细胞内NFκB通路和细胞自噬作用的分子机制, 2015-01至2018-12, 75.0000万元,已结题,参加
代表性研究成果(#为第一作者,*为通讯作者):
(1)Liaoxun Lu#; Junjian Hu#; Tianzhu Chao; Zhijun Chen; Zhuangzhuang Liu; Xinsong Luo; Yinming Liang; Pei He*;Lichen Zhang*;Loss of natural resistance to schistosome in T cell deficient rat,PLoS Neglected Tropical Diseases, 2020; 14(12): e0008909.
(2)Rong Huang#; Guo Guo#; Liaoxun Lu#; Rui Fu; Jing Luo; Zhuangzhuang Liu; Yanrong Gu; Wenyi Yang; Qianqian Zheng; Tianzhu Chao; Le He; Ying Wang; Zhiguo Niu; Hui Wang; Toby Lawrence; Marie Malissen; Bernard Malissen; Yinming Liang*;Lichen Zhang*;The three members of the Vav family proteins form complexes that concur to foam cell formation and atherosclerosis,The Journal of Lipid Research, 2019; 60(12): 2006-2019.
(3)Luo Jing#; Liaoxun Lu#; Yanrong Gu; Rong Huang; Lin Gui; Saichao Li; Xinhui Qi; Wenping Zheng; Tianzhu Chao; Qianqian Zheng; Yinming Liang*;Lichen Zhang*;Speed genome editing by transient CRISPR/Cas9 targeting and large DNA fragment deletion,Journal of Biotechnology, 2018;281: 11-20.
(4)Guillaume Voisinne; Kristof Kersse; Karima Chaoui; Liaoxun Lu; Julie Chaix;Lichen Zhang; Marisa Goncalves Menoita; Laura Girard; Youcef Ounoughene; Hui Wang; Odile Burlet-Schiltz; Hervé Luche; Frederic Fiore; Marie Malissen; Anne Gonzalez de Peredo; Yinming Liang*; Romain Roncagalli*; Bernard Malissen*;Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics,Nature Immunology, 2019; 20(11): 1530-+.
(5)Tianzhu Chao#; Liaoxun Lu#;Lichen Zhang#; Rong Huang; Zhuangzhuang Liu; Binhui Zhou; Eryan Kong; Zhongjian Zhang; Toby Lawrence*; Yinming Liang*;An inducible model for specific neutrophil depletion by diphtheria toxin in mice,Science China Life Sciences, 2021;64(8):1227-1235.
(6)Zhang Lichen, Li Wushan, Liu Zhuangzhuang, Liu Yang, Liu Zhilong, Gu Yanrong, He Le, Zhou Binhui, Li Tianhan, Chao Tianzhu, Liang Yinming*, Lu Liaoxun*: sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification.Frontiers in Cell and Developmental Biology, 2021;9:769673.
(7)Lichen Zhang, Rong Huang, Liaoxun Lu, Rui Fu, Guo Guo, Yanrong Gu, Zhuangzhuang Liu, Le He, Marie Malissen, Yinming Liang*; Gene Knock-in by CRISPR/Cas9 and Cell Sorting in Macrophage and T Cell Lines,Journal of Visualized Experiments, 2021;DOI: 10.3791/62328-v
(8)Shicong Zhai#; Cui Liu#;Lichen Zhang; Jian Zhu; Jiqiang Guo; Jinghang Zhang; Zhijun Chen; Wenping Zhou; Tingmin Chang; Siguang Xu; Yijun Qi; Ting Zhuang; Na Yu; Weilong Wang; Hui Wang; Sifan Yu; Xiumin Li*;PLCE1 Promotes Esophageal Cancer Cell Progression by Maintaining the Transcriptional Activity of Snail,NEOPLASIA, 2017;19(3): 154-164.
(9)Liaoxun Lu#*; Tianhan Li#; Xinyu Feng; Zhilong Liu; Yang Liu; Tianzhu Chao; Yanrong Gu; Rong Huang; Fanghui Zhang; Le He; Binhui Zhou; Eryan Kong; Zhuangzhuang Liu; Xugang Wang; Zhijun Chen; Hui Wang; Marie Malissen; Bernard Malissen;Lichen Zhang*; Yinming Liang*; Excessive immunosuppression by regulatory T cells antagonizes T cell response to schistosome infection in PD-1-deficient mice.PLoS Pathogens, 2022;18(6):e1010596.