卢燎勋(1984.10-),理学博士,副教授,硕士生导师,主要进行动物模型制作、动脉粥样硬化分子机理研究和血吸虫抗性免疫机理研究。
【受教育经历】
2003.09-2006.07,华中农业大学,生物技术专业 本科
2006.09-2013.07 华中农业大学,生物化学与分子生物学专业 博士
【研究工作经历】
2013.08-2014.03 中国种子集团 助理研究员
2014.04-2022.03 437必赢会员中心医学检验学院 讲师
2022.04-至今 437必赢会员中心医学检验学院 副教授
【承担及完成国家级/省级课题】
1.亚种杂交影响小鼠记忆T细胞形成的分子机制(81501342),国家自然科学基金青年项目,2016.01-2018.12,18万元;
2. Gfi1突变抑制CD36阳性单核细胞亚群分化及动脉粥样硬化形成的机制(U1904157),国家自然科学基金-河南省联合项目,2020.01-2022.12,49万元;
【代表性论著】(#为第一作者,*为通讯作者)
1. Wang Xugang#, Huang Rong#, Zhang Lichen, Li Saichao, Luo Jing, Gu Yanrong, Chen Zhijun, Zheng Qianqian, Chao Tianzhu, Zheng Wenping, Qi Xinhui, Wang Li, Wen Yinhang, Liang Yinming*,Lu Liaoxun*:A severe atherosclerosis mouse model on the resistant NOD background.Dis Model Mech,2018 ;11(10):dmm033852.
2. Huang Rong#, Guo Guo#,Lu Liaoxun#, Fu Rui, Luo Jing, Liu Zhuangzhuang, Gu Yanrong, Yang Wenyi, Zheng Qianqian, Chao Tianzhu, He Le, Wang Ying, Niu Zhiguo, Wang Hui, Lawrence Toby, Malissen Marie, Malissen Bernard, Liang Yinming*, Zhang Lichen*:The three members of the Vav family proteins form complexes that concur to foam cell formation and atherosclerosis.J Lipid Res ,2019;60(12):2006-2019.
3. Voisinne Guillaume, Kersse Kristof, Chaoui Karima,Lu Liaoxun, Chaix Julie, Zhang Lichen, Goncalves Menoita Marisa, Girard Laura, Ounoughene Youcef, Wang Hui, Burlet-Schiltz Odile, Luche Herve, Fiore Frederic, Malissen Marie, Gonzalez de Peredo Anne, Liang Yinming*, Roncagalli Romain*, Malissen Bernard*:Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.Nat Immunol ,2019;20(11):1530-1541.
4. Lu Liaoxun#, Hu Junjian#, Chao Tianzhu, Chen Zhijun, Liu Zhuangzhuang, Luo Xinsong, Liang Yinming*, He Pei*, Zhang Lichen*:Loss of natural resistance to schistosome in T cell deficient rat.PLoS Negl Trop Dis ,2020;14(12):e0008909.
5. Chao Tianzhu#,Lu Liaoxun#, Zhang Lichen, Huang Rong, Liu Zhuangzhuang, Zhou Binhui, Kong Eryan, Zhang Zhongjian, Lawrence Toby*, Liang Yinming*:An inducible model for specific neutrophil depletion by diphtheria toxin in mice.Sci China Life Sci2021;64(8):1227-1235.
6. Yuan Wei#,Lu Liaoxun#, Rao Muding, Huang Yang, Liu Chun-E, Liu Shuang, Zhao Yue, Liu Huicong, Zhu Jiangli, Chao Tianzhu, Wu Can, Ren Junyan, Lv Luxian, Li Wenqiang, Qi Shiqian, Liang Yinming, Yue Shijing, Gao Jian*, Zhang Zhongjian#, Kong Eryan*:GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice.Proc Natl Acad Sci U S A,2021 ;118(13):e2022261118.
7. Zhang Lichen, Li Wushan, Liu Zhuangzhuang, Liu Yang, Liu Zhilong, Gu Yanrong, He Le, Zhou Binhui, Li Tianhan, Chao Tianzhu, Liang Yinming*,Lu Liaoxun*:sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification.Front Cell Dev Biol ,2021;9:769673.
8. Liaoxun Lu#, Tianhan Li#, Xinyu Feng, Zhilong Liu, Yang Liu, Tianzhu Chao, Yanrong Gu, Rong Huang, Fanghui Zhang, Le He, Binhui Zhou, Eryan Kong, Zhuangzhuang Liu, Xugang Wang, Zhijun Chen, Hui Wang, Marie Malissen, Bernard Malissen, Lichen Zhang*, Yinming Liang*:Excessive immunosuppression by regulatory T cells antagonizes T cell response to schistosome infection in PD-1-deficient mice.PLOS Pathog,2022;DOI: 10.1371/journal.ppat.1010596.