梁银明,41岁,中共党员。实验室立足于小鼠模型探索疾病机制、开发了粒细胞缺陷等系列特色动物模型。取得了以下学术成绩:第一、首次发现RLTPR作为免疫应答关键调控“开关”,解开了T淋巴细胞共刺激信号传导之谜,相关结果在Nature Immunology发表(DOI 10.1038/ni.2634),该分子于2016年被《科学-细胞信号》评为细胞信号研究重大突破。第二、首次实现在小鼠活体水平对成熟T细胞内靶基因进行条件性剔除。该模型部分结果在Nature Immunology发表(DOI 10.1038/ni.2843)。第三、构建我国第一个免疫模式动物平台。平台拥有免疫研究相关动物模型品系超过300个,保存活体小鼠品系超过100个。第四、构建了小鼠及细胞系快速基因编辑方案,相关研究以共同通讯作者2019年10月在Nature Immunology发表,并获国内外媒体报道。近期研究结果以通讯作者在PLoS Pathogens、EMBO Reports、SCIENCE CHINA Life Sciences等国际著名期刊发表。在动物模型构建技术及基础研究方面取得了系列进步。研发了新一代人源化小鼠,在国外动物模型的基础上,实现了粒细胞缺失,进一步优化了人源化受体小鼠方案。实验室聚焦免疫相关重大疾病动物模型研究及致病机制研究,是我国该领域最为活跃的实验室之一。
【受教育经历】
2009年9月–2013年10月,Aix-Marseille大学,免疫学博士
2006年9月–2009年6月,东华大学,生物化学与分子生物学硕士
1999年9月–2004年6月,湖南中医药大学,中医学,学士
【研究工作经历】
2013.11-至今 437必赢会员中心医学检验学院 讲师、特聘教授
【承担及完成国家级/省级课题】
1.河南省杰出青年科学基金项目,222300420015,慢性炎症机制及动物模型研究,2022年1月至2024年12月,在研,主持
2.国家自然科学基金面上项目,32070898,LAT介导的负反馈障碍导致T细胞增殖失控的机制,2021年1月至2024年12月,在研,主持
【代表性论著】(#为第一作者,*为通讯作者)
1. Liaoxun Lu*, Tianhan Li, Xinyu Feng, Zhilong Liu, Yang Liu, Tianzhu Chao, Yanrong Gu, Rong Huang, Fanghui Zhang, Le He, Binhui Zhou, Eryan Kong, Zhuangzhuang Liu1, Xugang Wang, Zhijun Chen, Hui Wang, Marie Malissen, Bernard Malissen, Lichen Zhang*,Yinming Liang*. Excessive immunosuppression by regulatory T cells antagonizes T cell response to schistosome infection in PD-1-deficient mice .PLOS PATHOGENS. 2022;18(6): e1010596.
2. Wenyi Yang, Binhui Zhou,QiLiu, Taozhen Liu, Huijie Wang, Pei Zhang, Liaoxun Lu, Lichen Zhang, Fanghui Zhang, Rong Huang , Jitong Zhou, Tianzhu Chao,Yanrong Gu, Songhua Lee, Hui Wang *,Yinming Liang*and Le He*. A Murine Point Mutation ofSgpl1Skin Is Enriched With Vg6IL17-Producing Cell and Revealed With Hyperpigmentation After Imiquimod Treatment. Frontiers in Immunology.Frontiers in Immunology.2022;2022.728455
3. He L, Valignat MP, Zhang L, Gelard L, Zhang F, Le Guen V, Audebert S, Camoin L, Fossum E, Bogen B, Wang H, Henri S, Roncagalli R, Theodoly O,Liang Y*, Malissen M*, Malissen B*. ARHGAP45 controls naive T- and B-cell entry into lymph nodes and T-cell progenitor thymus seeding.EMBO Rep. 2021;22:e52196.
4. Wang Y, Fu Z, Li X,Liang Y, Pei S, Hao S, Zhu Q, Yu T, Pei Y, Yuan J, Ye J, Fu J, Xu J, Hong J, Yang R, Hou H, Huang X, Peng C, Zheng M, Xiao Y. Cytoplasmic DNA sensing by KU complex in aged CD4(+) T cell potentiates T cell activation and aging-related autoimmune inflammation.Immunity. 2021;54:632-647 e639.
5. Chao T, Lu L, Zhang L, Huang R, Liu Z, Zhou B, Kong E, Zhang Z, Lawrence T*,Liang Y*. An inducible model for specific neutrophil depletion by diphtheria toxin in mice.Sci China Life Sci.2021;64:1227-1235.
6. Zhang L, Huang R, Lu L, Fu R, Guo G, Gu Y, Liu Z, He L, Malissen M,Liang Y*. Gene Knock-in by CRISPR/Cas9 and Cell Sorting in Macrophage and T Cell Lines.J Vis Exp. 2021.
7. Zheng Q, Duan L, Lou Y, Chao T, Guo G, Lu L, Zhang H, Zhao Y,Liang Y*, Wang H*. Slfn4 deficiency improves MAPK-mediated inflammation, oxidative stress, apoptosis and abates atherosclerosis progression in apolipoprotein E-deficient mice.Atherosclerosis. 2021;337:42-52.
8. Zhou B, Lawrence T,Liang Y*. The Role of Plasmacytoid Dendritic Cells in Cancers.Front Immunol. 2021;12:749190.
9. Lu L, Hu J, Chao T, Chen Z, Liu Z, Luo X,Liang Y, He P, Zhang L. Loss of natural resistance to schistosome in T cell deficient rat.PLoS Negl Trop Dis. 2020;14:e0008909.
10. Voisinne G, Kersse K, Chaoui K, Lu L, Chaix J, Zhang L, Goncalves Menoita M, Girard L, Ounoughene Y, Wang H, Burlet-Schiltz O, Luche H, Fiore F, Malissen M, Gonzalez de Peredo A,Liang Y*, Roncagalli R*, Malissen B*. Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.Nat Immunol. 2019;20:1530-1541.
11. Huang R, Guo G, Lu L, Fu R, Luo J, Liu Z, Gu Y, Yang W, Zheng Q, Chao T, He L, Wang Y, Niu Z, Wang H, Lawrence T, Malissen M, Malissen B,Liang Y*,
Zhang L*. The three members of the Vav family proteins form complexes that concur to foam cell formation and atherosclerosis.J Lipid Res. 2019;60:2006-2019.
12. Chao T, Liu Z, Zhang Y, Zhang L, Huang R, He L, Gu Y, Chen Z, Zheng Q, Shi L, Zheng W, Qi X, Kong E, Zhang Z, Lawrence T,Liang Y*, Lu L*. Precise and Rapid Validation of Candidate Gene by Allele Specific Knockout With CRISPR/Cas9 in Wild Mice.Front Genet. 2019;10:124.
13. Luo J, Lu L, Gu Y, Huang R, Gui L, Li S, Qi X, Zheng W, Chao T, Zheng Q,Liang Y*, Zhang L*. Speed genome editing by transient CRISPR/Cas9 targeting and large DNA fragment deletion.J Biotechnol. 2018;281:11-20.
14. Wang X, Huang R, Zhang L, Li S, Luo J, Gu Y, Chen Z, Zheng Q, Chao T, Zheng W, Qi X, Wang L, Wen Y,Liang Y*, Lu L*. A severe atherosclerosis mouse model on the resistant NOD background.Dis Model Mech. 2018;11.
15. Zhang X, Wang Y, Yuan J, Li N, Pei S, Xu J, Luo X, Mao C, Liu J, Yu T, Gan S, Zheng Q,Liang Y, Guo W, Qiu J, Constantin G, Jin J, Qin J, Xiao Y. Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3.J Exp Med. 2018;215:1365-1382.
16. Roncagalli R, Cucchetti M, Jarmuzynski N, Gregoire C, Bergot E, Audebert S, Baudelet E, Menoita MG, Joachim A, Durand S, Suchanek M, Fiore F, Zhang L, LiangY, Camoin L, Malissen M, Malissen B. The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells.J Exp Med. 2016;213:2437-2457.
17. Roncagalli R, Hauri S, Fiore F,Liang Y, Chen Z, Sansoni A, Kanduri K, Joly R, Malzac A, Lahdesmaki H, Lahesmaa R, Yamasaki S, Saito T, Malissen M, Aebersold R, Gstaiger M, Malissen B. Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.Nat Immunol. 2014;15:384-392.
18. Liang Y, Cucchetti M, Roncagalli R, Yokosuka T, Malzac A, Bertosio E, Imbert J, Nijman IJ, Suchanek M, Saito T, Wulfing C, Malissen B, Malissen M. The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.Nat Immunol. 2013;14:858-866.
19. Ordonez-Rueda D, Jonsson F, Mancardi DA, Zhao W, Malzac A,Liang Y, Bertosio E, Grenot P, Blanquet V, Sabrautzki S, de Angelis MH, Meresse S, Duprez E, Bruhns P, Malissen B, Malissen M. A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia.Eur J Immunol. 2012;42:2395-2408.
【获得的科研奖励和荣誉】
1. 2021年度河南高等教育突出贡献人物,河南日报社黄河教育奖组委会,2021年
2. 河南省高等学校优秀共产党员,中共河南省委高等学校工作委员会,2020年
3. 河南省优秀硕士学位论文指导教师,河南省教育厅,省级,2018年
4. 五一劳动奖章,新乡市总工会,2017年
5. 中国免疫学会青年学者奖,中国免疫学会,2014年
【学术任职】
河南省实验动物学会副理事长
Frontiers in Immunology审稿编辑、Nature Immunology论文评审