朱小飞，1976.05-，北京协和医学院医药生物技术研究所，医学博士。437必赢会员中心医学检验学院院长，硕士生导师。研究方向为肿瘤免疫学与感染免疫学，主要从事肿瘤靶向药物、HTLV-1病毒与宿主的免疫调控机制、代谢性疾病免疫异常的分子机制研究。主持国家自然科学基金面上项目2项，河南高校创新人才项目1项，河南省教育厅青年骨干教师项目1项。在Clinic Cancer Research、Oncotarget等SCI期刊上发表论文11篇，中文核心期刊6篇，为Current drug metabolism、Diagnostic Pathology等期刊审稿人。为国家“十二五”《临床免疫学检验》数字教材编委，《临床免疫学检验技术实验指导》编委，全国普通高等教育医学检验技术类系列教材《临床免疫检验学》副主编，译著《肝脏免疫学：基础与临床》编委。

学术任职：

中国免疫学会会员，

中国免疫学会青年工作委员会委员

河南免疫学会常委理事

发表SCI论文一览表（#为第一作者，*为通讯作者）：

1. Guo X, Yin X, Zhu W, Pan Y, Wang H, Liang Y, Zhu X*. The preconditioning of Busulfan promotes efficiency of human CD133+ cell engraftment in NOD Shi-SCID IL2Rγc null (NOG) mice via intra-bone marrow injection. Cell Transplant. 2019, 963689719842162.

2. Zhu X#*, Yang J, Zhu W, Yin X, Yang B, Wei Y, Guo X. Combination of Berberine with Resveratrol Improves the Lipid-Lowering Efficacy. Int J Mol Sci. 2018 Dec 6;19(12)

3. Guo XF, Li SS, Zhu XF, Dou QH, Liu D.Lapatinib in combination with paclitaxel plays synergistic antitumor effects on esophageal squamous cancer.Cancer Chemother Pharmacol. 2018 Sep;82(3):383-394

4. Zhu X#*, Yue H, Guo X, Yang J, Liu J, Liu J, Wang R, Zhu W. The Preconditioning of Berberine Suppresses Hydrogen Peroxide-Induced Premature Senescence via Regulation of Sirtuin 1. Oxid Med Cell Longev. 2017,2391820.

5. He J, Mai J, Li Y, Chen L, Xu H, Zhu X*, Pan Q. miR-597 inhibits breast cancer cell proliferation, migration and invasion through FOSL2. Oncol Rep. 2017 May;37(5):2672-2678.

6. Guo XF, Zhu XF, Cao HY, Zhong GS, Li L, Deng BG, Chen P, Wang PZ, Miao QF, Zhen YS. A bispecific enediyne-energized fusion protein targeting both epidermal growth factor receptor and insulin-like growth factor 1 receptor showing enhanced antitumor efficacy against non-small cell lung cancer. Oncotarget. 2017 Apr 18;8(16):27286-27299.

7. Cao HY, Guo XF, Zhu XF, Li SS, Zhen YS. A ligand-based and enediyne-energized bispecific fusion protein targeting epidermal growth factor receptor and insulin-like growth factor-1 receptor shows potent antitumor efficacy against esophageal cancer. Oncol Rep. 2017 Jun;37(6):3329-3340.

8. Guo XF#, Zhu XF#, Yang WC 3, Zhang SH 4, ZhenYS 4. An EGFR/HER2-Bispecific and enediyne-energized fusion protein shows highefficacy against esophageal cancer. PLoS One. 2014 Mar 24;9(3):e92986.

9. Zhu X#*, Guo X, Mao G, GaoZ, Wang H, He Q, Li D. Hepatoprotection of berberine against hydrogenperoxide-induced apoptosis by upregulation of Sirtuin 1. Phytother Res. 2013, 7(3):417-21.

10. Guo XF, Zhu XF, Zhong GS, Deng BG, Gao ZT, Wang H. Lapatinib, a dual inhibitor of EGFR and HER2, has synergistic effects with 5-fluorouracil on esophageal carcinoma. Oncol Rep. 2012 May; 27(5):1639-45.

11. Guo XF#, Zhu XF#, Shang Y, Zhang SH, Zhen YS. A bispecific enediyne-energized fusion protein containing ligand-based and antibody-based oligopeptides against epidermal growth factor receptor and human epidermal growth factor receptor 2 shows potent antitumor activity. Clin Cancer Res. 2010 Apr 1; 16(7):2085-94

    
    

    主持的重大科研项目：

    [1] SIRT4调节T细胞代谢信号影响肥胖症免疫反应的机制研究，国家自然科学基金面上项目，55，2018.01-2021.12，

    [2] Sirt1维持HTLV-1感染T细胞持续性潜伏的作用及分子机制，国家自然科学基金面上项目，75，2014.01-2017.12，

    [3] sirtuins蛋白家族对肥胖者免疫细胞功能异常的分子调控机制研究，河南省高校科技创新人才支持计划，60，2015.01-2017.12，

    [4] Sirtuins蛋白家族与肥胖者免疫细胞功能状态异常相关性研究及分子机制探讨，河南省高校自然科学重点项目，4，2015.01-2017.12，

    获批专利：

    一种可弹出胰岛素笔针头的针帽装置（201721690508.4）专利权人：尹肖肖, 郭晓芳, 朱小飞，尹肖月

    近年来获得的成果奖：

    朱小飞6/7，成人T淋巴细胞白血病相关基因的研究与应用，河南省人民政府省级，三等奖，2014，第六

    朱小飞4/8，旨在增强力达霉素抗肿瘤活性的靶向性融合蛋白的构建及活性检测，河南省人民政府省级，三等奖，2019，第四