王洁，1982.06-，中国科学院上海生命科学研究院生物化学与细胞生物学研究所细胞生物学博士学位。2013年入选437必赢会员中心首批“太行青年学者”。目前研究方向为分子免疫学，主要从事宿主抗病毒免疫机制研究。主持国家自然科学基金3项；以第一作者或通讯作者在Cellular & Molecular Immunology、J Immunol、FEBS Letter、Scientific Reports等杂志上发表论文8篇。 学术任职： 中国免疫学会会员 发表SCI论文一览表（#为第一作者，*为通讯作者） Yang B, Song D, Liu Y, Cui Y, Lu G, Di W, Xing H, Ma L, Guo Z, Guan Y, Wang H, Wang J*. IFI16 regulates HTLV-1 replication through promoting HTLV-1 RTI-induced innate immune responses. FEBS Lett. 2018 May; 592(10):1693-1704. doi: 10.1002/1873-3468.13077. IF=2.99 Wang J#, Song D, Liu Y, Lu G, Yang S, Liu L, Gao Z, Ma L, Guo Z, Zhang C,Wang H, Yang B. HLA-DMB restricts human T-cell leukemia virus type-1 (HTLV-1) protein expression via regulation of ATG7 acetylation. Sci Rep. 2017 Oct 31;7(1):14416. doi: 10.1038/s41598-017-14882-z. IF=4.8 Jie Wang#, Lixia Kang, Lu Liu, Shuai Yang, Di Song, Lingling Ma, Zhixiang Guo, Huaxia Ding, Hui Wang and Bo Yang. Ku70 senses the HTLV-1 DNA and modulates HTLV-1 replication. The Journal of immunology. 2017 Oct 1; 199(7):2475-2482. doi: 10.4049/jimmunol.1700111. IF=4.8 Jie Wang#, Shuai Yang, Lu Liu, Hui Wang and Bo Yang. HTLV-1 Tax impairs K63-linked ubiquitination of STING to evade host innate immunity. Virus research. 2017 Mar 15; 232:13-21. doi: 10.1016/j.virusres.2017.01.016. IF=2.7 Jie Wang#, Bo Yang, Yu Hu, Yuhan Zheng, Leilei Yang, Meilin Qin and Bing Sun. Negative regulation of Nmi on virus-triggered type I IFN production by targeting IRF7. The Journal of immunology. 2013 Sep 15; 191(6):3393-9. doi: 10.4049/jimmunol. IF=4.8 Bo Yang, Jie Wang#, Yanming Wang, Haiyan Zhou, Xiaodong Wu, Zhigang Tian, and Bing Sun. Novel function of Trim44 promotes an antiviral response by stabilizing VISA. The Journal of immunology. 2013 Apr 1; 190(7):3613-9. doi: 10.4049/jimmunol. IF=4.8 Yu Hu , Jie Wang#, Bo Yang, Meilin Qin, Yongyong Ji, Guomei Lin, Lin Tian, Xiaodong Wu and Bing Sun. Guanylate binding protein (GBP) 4 negatively regulates virus induced type I interferon and antiviral response by targeting interferon regulatory factor (IRF) 7.The Journal of immunology. 2011 Dec 15; 187(12):6456-62. doi: 10.4049/jimmunol.1003691. IF=4.8 Jie Wang#, Yu Hu , Wei Wen Deng, Bing Sun. Negative regulation of Toll-like receptor signaling pathway. Microbes and Infection. 2009 Mar; 11(3):321-7. doi: 10.1016/j.micinf.2008.12.011.IF=2.7
主持的重大科研项目： RNF144A调控MITA/STING介导的固有免疫应答反应的功能和机制研究，王洁，国家自然科学基金 2020.01-2023.12，No. 31970847，59万元； RNF90调控MITA/STING介导的胞内抗病毒应答反应的研究，王洁，国家自然科学基金 2017.01-2019.12，No. 31600697，20万元； Ku70负性调控HTLV-1病毒感染的功能和机制研究，王洁，国家自然科学基金 2016.01-2018.12，No. U1504811，27万元；
近五年来获批专利： S100A10 mRNA在α-干扰素诱导抑郁症中的作用(201510165415.9)，专利权人：王辉、郭继强、张文、杨波、王洁、丁华夏、李桂芬
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