杨林林
发布时间:2021-01-21 浏览次数:

杨林林,男,1989年出生。应用化学博士,副教授,硕士研究生导师。中国化学会会员。目前主要从事超分子化学和荧光探针的生物医学应用研究,擅长荧光探针的设计合成及荧光成像应用。主持参与河南省科技厅、河南省教育厅等项目4项,以第一或通讯作者已先后在国际权威SCI期刊发表论文9篇,其中中科院一区论文5篇。

 

联系方式

电话:18336095015

Email:yanglin1989728@163.com

学习经历

2010/09-2017/06:大连理工大学,应用化学,博士

2006/09-2010:07:大连理工大学,应用化学,学士

工作经历

2023/03-至今:437必赢会员中心,法医学院,副教授

2017/07-2023/02:437必赢会员中心,法医学院,讲师

研究方向

荧光探针的设计合成及生物医学应用

主要科研工作

1.具体研究领域

小分子荧光探针的生物荧光成像

2.课题资助

(1)河南省科技攻关项目,基于金属有机笼状结构的超分子比率荧光探针的构建及在肿瘤成像方面的应用研究,2023.01-2024.12,主持

(2)河南省高等学校重点科研项目,面向高β-立体选择性Koenigs-Knorr糖基化反应的金属有机超分子反应器的研究,2021.01-2022.12,主持

3.获奖成果

科学技术成果:肿瘤靶向小分子荧光前药的设计合成及应用

4.近期代表性论文

(1)Linlin Yang&, Pengli Gu&, Beining Li, Junwan Li, Aoxiang Fu, Xianyu Gong, Yanmei Huang, Lixia Xie, Liguo Ji, Nana Ma*, Lili Li*, Guangjie He*. A homocysteine-selective fluorescent probe for cell imaging based on substitution-rearrangement process. Dyes and Pigments. 2022, 207: 110802.

(2)Pengli Gu, Lili Li, Aoxiang Fu, Huina Song, Bin Zhao, Lai Wei, Liguo Ji, Wenqiang Li*, Ruiling Zhang, Qingzhi Wang, Guangjie He*,Linlin Yang*. High-performance fluorescence probe for fast and specific visualization of norepinephrine in vivo and depression-like mice. Bioorganic Chemistry. 2023, 131: 106306.

(3)Linlin Yang&, Nan Yang&, Pengli Gu, Yihua Zhang, Xianyu Gong, Shichao Zhang, Junwan Li, Liguo Ji*, Guangjie He*. A novel naphthalimide-based fluorescent probe for the colorimetric and ratiometric detection of SO2 derivatives in biological imaging. Bioorganic Chemistry. 2022,123, 105801.

(4)Linlin Yang*, Nan Yang, Pengli Gu, Chuang Wang, Beining Li, Yihua Zhang, Liguo Ji, Guangjie He*. A novel flavone-based ESIPT ratiometric fluorescent probe for selectivesensing and imaging of hydrogen polysulfides. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2022, 271: 120962.

(5)Linlin Yang*, Yanping Li, Huaxiong Song, Haihua Zhang, Nan Yang, Qian Peng, Liguo Ji, Guangjie He*. A highly sensitive probe based on spiropyran for colorimetric and fluorescent detection of thiophenol in aqueous media. Dyes and Pigments. 2020, 175, 108154.

(6)Linlin Yang&, Pengli Gu&, Aoxiang Fu, Yanbei Xi, Shaoli Cui, Liguo Ji, Lili Li*,Nana Ma, Qingzhi Wang*, Guangjie He*. TPE-based fluorescent probe for dual channel imaging of pH/viscosity and selective visualization of cancer cells and tissues. Talanta. 2023, 265, 124862.

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